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Figures 5, 6 & 7 represent data from an independent POC evaluation of the Scientec technology. The graphical representations are the mean antibody titers [Ab] against time for a 5 component commercial antigen mixture given as (i) the conventional 2 dose liquid formulation at days 0 and 21 (Figure 5), (ii) a 'naked' solid dose together with a non irradiated 21 day CRD, also at day 0 (Figure 6) and (iii) a 'naked' solid dose together with an irradiated 21 day CRD at day 0 (Figure 7). The study was conducted in sheep.
The data show bioavailability from both the 'naked' and CRD formulations, with responses to a number of the antigens (particularly antigen 2) from the 'naked' plus CRD formulations being comparable to or greater than those obtained from the conventional liquid vaccine Control group. Interestingly antigen 2 also appeared very sensitive to sterilizing irradiation. Parallel studies in mice corroborated these data.
Figure 5: Antibody responses of sheep vaccinated with the 'Control' liquid vaccine at days 0 and 21
Figure 6: Antibody response of sheep vaccinated with a 'naked' solid dose plus a day 21 CRD, both at day 0. The CRD formulation was not irradiated prior to implantation.
Figure 7: Antibody response of sheep vaccinated with a 'naked' solid dose plus a day 21 CRD, both at day 0. The CRD formulation was irradiated prior to implantation.
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